NR-5 TM technology | Regenerate

NR-5™ TECHNOLOGY

Over 10 years of research across Unilever global centres led to the development of NR-5™ technology resulting in 5 international patents*.
*awarded and pending

REGENERATE™ ENAMEL SCIENCE WITH NR-5™ TECHNOLOGY

REGENERATE™ Enamel Science Advanced Toothpaste and Advanced Enamel Serum with breakthrough NR-5™ technology, contains calcium silicate and sodium phosphate salts, which combine to form a fresh supply of enamel minerals.

Clinically proven to restore lost enamel mineral content by forming hydroxyapatite¹, the same mineral as tooth enamel. Enamel is naturally 96% hydroxyapatite.

REGENERATE™ Advanced Toothpaste for twice daily brushing, protects and strengthens against caries, for 3 times stronger teeth².

In an in-vitro study 82% of enamel mineral was regenerated after 3 days’ use of Advanced Toothpaste and Advanced Enamel Serum³.

ADVANCED TOOTHPASTE

FLUORIDE-ONLY TOOTHPASTE

After twice-daily brushing with Advanced Toothpaste for 4 weeks, scanning electron micrographs showed hydroxyapatite-mineral layers deposited onto the enamel surface. In contrast, when enamel samples were brushed with fluoride-only toothpaste no deposits were observed.

Sun Y, Li X, Deng Y, et al. J Dent 2014;42 Suppl 1:S30–S38

REGENERATE™ ENAMEL SCIENCE WITH NR-5™ TECHNOLOGY

Clinically proven to restore lost enamel mineral content by forming hydroxyapatite¹, the same mineral as tooth enamel. Enamel is naturally 96% hydroxyapatite.

REGENERATE™ Advanced Toothpaste for twice daily brushing, protects and strengthens against caries, for 3 times stronger teeth².

In an in-vitro study 82% of enamel mineral was regenerated after 3 days’ use of Advanced Toothpaste and Advanced Enamel Serum³.

PROVEN IDENTICAL CRYSTAL STRUCTURE AND CHEMICAL COMPOSITION TO ENAMEL

Microscopy and spectroscopy data demonstrated that the new hydroxyapatite has identical crystal structure and chemical composition to enamel mineral.

Sun Y, Li X, Deng Y, et al. J Dent 2014;42 Suppl 1:S30–S38

PROVEN TO REMINERALISE 82% OF ENAMEL AFTER 3 DAYS³

In-vitro assessment of remineralisation of acid-softened enamel samples showed that the REGENERATE™ Enamel Science system provides significant recovery of enamel hardness after 3 days.

Hornby K, Ricketts SR, Philpotts CJ, et al. J Dent 2014;42 Suppl 1:S39–S45

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SUPERIOR RECOVERY OF ENAMEL HARDNESS

Clinically proven to provide superior enamel re-hardening after 3 days’ combined use of REGENERATE™ Advanced Toothpaste and Advanced Enamel Serum compared with a standard fluoride toothpaste.

Joiner A, Schafer F, Naeeni MM, et al. J Dent 2014;42 Suppl 1:S53–59

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SUPERIOR PROTECTION AGAINST ENAMEL EROSION

After 7 days’ application and frequent acid challenges, the combined use of REGENERATE™ Advanced Toothpaste and Advanced Enamel Serum showed two times greater protection from erosion than a fluoride-only toothpaste.

Wood NJ, Jones SB, Chapman N, et al. Dent Mater 2017;34:355–362

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LEARN MORE ABOUT NR-5™ TECHNOLOGY

Unilever is committed to scientific research in the field of enamel erosion. Watch this space to stay up-to-date with the very latest evidence. Download a summary booklet containing all the studies that support NR-5™ technology.

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NR-5™ TECHNOLOGY

REGENERATE™ ENAMEL SCIENCE WITH NR-5™ TECHNOLOGY

PROVEN TO FORM HYDROXYAPATITE MINERAL

ADVANCED TOOTHPASTE

FLUORIDE-ONLY TOOTHPASTE

PROVEN TO FORM HYDROXYAPATITE MINERAL

PROVEN IDENTICAL CRYSTAL STRUCTURE AND CHEMICAL COMPOSITION TO ENAMEL

REGENERATE™ ENAMEL SCIENCE WITH NR-5™ TECHNOLOGY

PROVEN IDENTICAL CRYSTAL STRUCTURE AND CHEMICAL COMPOSITION TO ENAMEL

PROVEN TO REMINERALISE 82% OF ENAMEL AFTER 3 DAYS³

SUPERIOR RECOVERY OF ENAMEL HARDNESS

SUPERIOR PROTECTION AGAINST ENAMEL EROSION

LEARN MORE ABOUT NR-5™ TECHNOLOGY

LEARN MORE ABOUT NR-5™ TECHNOLOGY